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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Lexicon for blood-based early detection and screening: BLOODPAC consensus document.

Christina A Clarke1, Breeana L Mitchell2, Girish Putcha3

  • 1GRAIL, Menlo Park, California, USA.

Clinical and Translational Science
|August 29, 2024
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Summary
This summary is machine-generated.

Novel blood tests aim to detect cancers early, before symptoms appear. The Blood Profiling Atlas in Cancer (BLOODPAC) consortium developed a shared lexicon to standardize terminology for these single- and multi-cancer detection (SCD and MCD) tests, aiding development and adoption.

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Medical Diagnostics

Background:

  • Cancer remains a leading cause of death in the US, with 2.0 million new cases and 600,000 deaths estimated in 2024.
  • Early cancer detection significantly improves treatment success rates.
  • Current cancer screening is limited to a few cancer types, leaving many unscreened.

Purpose of the Study:

  • To address the need for standardized terminology in the rapidly evolving field of non-invasive cancer detection.
  • To accelerate the development, access, and adoption of single- and multi-cancer detection (SCD and MCD) tests.
  • To establish a foundational lexicon for the Early Detection & Screening (ED&S) Working Group of the Blood Profiling Atlas in Cancer (BLOODPAC) Consortium.

Main Methods:

  • Compilation of a lexicon of 14 primary terms relevant to SCD and MCD tests.
  • Selection criteria included perceived importance, frequency of use, lack of clarity, and unique challenges.
  • The lexicon was submitted to the Food and Drug Administration (FDA) for feedback and incorporated revisions.

Main Results:

  • The ED&S Working Group has compiled and presents the first installment of a standardized lexicon for cancer detection tests.
  • This lexicon aims to harmonize terminology among diverse stakeholders in the early cancer detection field.
  • The presented terms will form part of an online dictionary to support future BLOODPAC initiatives.

Conclusions:

  • Standardized definitions are crucial for clear communication and progress in the field of early cancer detection.
  • The developed lexicon provides a foundation for consistent terminology in the development and regulation of novel cancer screening tests.
  • This initiative by the BLOODPAC's ED&S Working Group is a key step towards advancing the discipline of early cancer detection.