Prevalence of CT-detected extramural vascular invasion in gastric adenocarcinoma and its correlation with other known prognostic factors
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View abstract on PubMed
Summary
This summary is machine-generated.Extramural vascular invasion (EMVI) is common in advanced gastric cancer, detected via CT scans. This finding significantly correlates with tumor stage, metastases, and treatment response, marking it a key prognostic indicator.
Area Of Science
- Oncology
- Radiology
- Medical Imaging
Background
- Gastric adenocarcinoma (GA) is a significant cause of cancer-related mortality worldwide.
- Accurate prognostic markers are crucial for effective treatment planning in GA.
- Extramural vascular invasion (EMVI) is an emerging prognostic factor in various solid tumors.
Purpose Of The Study
- To determine the prevalence of EMVI on computed tomography (CT) in patients with GA.
- To investigate the association between CT-detected EMVI (ct-EMVI) and established prognostic factors in GA.
- To evaluate ct-EMVI as a potential imaging biomarker for predicting treatment response and patient outcomes.
Main Methods
- Retrospective analysis of 191 GA patients who underwent staging CT.
- Two radiologists assessed CT scans for EMVI presence and grade.
- Correlation of ct-EMVI findings with tumor characteristics, TNM stage, and response to neoadjuvant chemotherapy (NAC).
Main Results
- ct-EMVI was detected in 65% of GA patients, with higher prevalence in advanced T stages (86% in T4).
- Significant associations were found between ct-EMVI and tumor thickness, TNM stage, and presence of metastases (peritoneal, lymph node, liver).
- ct-EMVI was also significantly associated with the response to NAC.
Conclusions
- EMVI is frequently observed on staging CT in advanced GA.
- ct-EMVI serves as a significant imaging biomarker, correlating with TNM stage, peritoneal metastases, and NAC response.
- Incorporating ct-EMVI assessment into routine staging CT may improve prognostic accuracy and treatment guidance for GA patients.
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