Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tuning lipid nanocarrier mechanical properties to improve glioblastoma targeting and blood brain barrier penetration.

Nanoscale·2025
Same author

Sex ratio and age of onset in AQP4 antibody-associated NMOSD: a review and meta-analysis.

Journal of neurology·2024
Same author

Upregulation of the secretory pathway Ca<sup>2+</sup>/Mn<sup>2+</sup>-ATPase isoform 1 in LPS-stimulated microglia and its involvement in Mn<sup>2+</sup>-induced Golgi fragmentation.

Glia·2024
Same author

Providing an <i>in vitro</i> depiction of microglial cells challenged with immunostimulatory extracellular vesicles of <i>Naegleria fowleri</i>.

Frontiers in microbiology·2024
Same author

New insights into the role of the endoplasmic reticulum in microglia.

Neural regeneration research·2023
Same author

Distribution of intracellular Ca<sup>2+</sup>-ATPases in the mouse retina and their involvement in light-induced cone degeneration.

Biochimica et biophysica acta. Molecular cell research·2023

Related Experiment Video

Updated: Jun 14, 2025

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons
07:38

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons

Published on: June 8, 2014

18.3K

Microglial Phagocytosis During Embryonic and Postnatal Development.

José L Marín-Teva1, M Rosario Sepúlveda2, Veronika E Neubrand2

  • 1Department of Cell Biology, Faculty of Sciences, University of Granada, Granada, Spain. jlmarin@ugr.es.

Advances in Neurobiology
|August 29, 2024
PubMed
Summary
This summary is machine-generated.

Microglia, the brain's immune cells, are essential for central nervous system (CNS) development. Their phagocytosis function, or cell eating, is critical for clearing debris and shaping neural connections.

Keywords:
DevelopmentEngulfment-promoted cell deathMicrogliaPhagocytosisPhagoptosisSynaptic pruning

More Related Videos

In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
09:48

In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages

Published on: February 14, 2021

5.5K
Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development
07:45

Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development

Published on: May 17, 2024

1.1K

Related Experiment Videos

Last Updated: Jun 14, 2025

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons
07:38

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons

Published on: June 8, 2014

18.3K
In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
09:48

In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages

Published on: February 14, 2021

5.5K
Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development
07:45

Author Spotlight: Using Zebrafish to Explore Microglia Migration During Brain Development

Published on: May 17, 2024

1.1K

Area of Science:

  • Neuroscience
  • Immunology
  • Developmental Biology

Background:

  • Microglia are the primary immune cells of the central nervous system (CNS).
  • Phagocytosis, the process of engulfing and removing cells or debris, is a key microglial function.
  • Microglial phagocytosis is crucial throughout embryonic and postnatal brain development.

Purpose of the Study:

  • To elucidate the multifaceted roles of microglial phagocytosis in CNS development.
  • To detail the mechanisms and functions of microglial phagocytic activity.
  • To highlight how microglia act as professional phagocytes in the developing brain.

Main Methods:

  • Review of existing literature on microglial function and phagocytosis.
  • Analysis of the spatiotemporal regulation of microglial phagocytic receptors.
  • Detailed description of the phagocytic process in microglial cells.

Main Results:

  • Microglial phagocytosis is involved in clearing cellular debris, preventing inflammation.
  • Phagocytosis by microglia regulates the number of neuronal and glial cells.
  • Microglia contribute to axon guidance and synaptic refinement through phagocytosis.

Conclusions:

  • Microglial phagocytosis is indispensable for normal brain development.
  • Receptor modulation allows microglia to adapt their phagocytic functions to developmental needs.
  • Understanding microglial phagocytosis provides insights into CNS development and potential therapeutic targets.