Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

3.8K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
3.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

67.9K
Overview
67.9K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

2.6K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
2.6K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

2.6K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sialylation patterns in cerebral amyloid angiopathy.

Brain pathology (Zurich, Switzerland)·2025
Same author

Genetic polymorphisms in human CX<sub>3</sub>CR1-mediated macrophage dysregulation are associated with the worsening of hearing loss and cochlear degeneration after noise trauma: a study in a humanized mouse model.

Journal of neuroinflammation·2025
Same author

The influence of clinical risk factors on the classification of human cancer-associated fibroblasts in PDAC and pancreatitis patients.

BJC reports·2025
Same author

Genetic Polymorphisms in Human CX3CR1-Mediated Macrophage Dysregulation are Associated with the Worsening of Hearing Loss and Cochlear Degeneration After Noise Trauma: A Study in a Humanized Mouse Model.

Research square·2025
Same author

Suppression of BRCA1 facilitates kidney regeneration.

The Journal of experimental medicine·2025
Same author

CX3CR1-Fractalkine Dysregulation Affects Retinal GFAP Expression, Inflammatory Gene Induction, and LPS Response in a Mouse Model of Hypoxic Retinopathy.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Jun 14, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1&#946; in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

20.9K

Roles in Innate Immunity.

Kaira A Church1,2, Astrid E Cardona1,2, Sarah C Hopp3

  • 1Department of Molecular Microbiology & Immunology, The University of Texas at San Antonio, San Antonio, TX, USA.

Advances in Neurobiology
|August 29, 2024
PubMed
Summary
This summary is machine-generated.

Microglia, the brain's immune cells, regulate inflammation and immune responses in the central nervous system (CNS). Their interactions with other immune cells balance neuroprotection and damage, influencing disease outcomes.

Keywords:
Antigen presentationBBBImmune-surveillanceInflammasomeMicrogliaMicroglia sensomePhagocytosisVasculature

More Related Videos

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.4K
Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

8.8K

Related Experiment Videos

Last Updated: Jun 14, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1&#946; in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

20.9K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.4K
Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
11:44

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo

Published on: September 18, 2014

8.8K

Area of Science:

  • Neuroimmunology
  • Central Nervous System (CNS) Immunity

Background:

  • Microglia are the primary immune cells residing in the brain.
  • They are crucial for managing inflammation within the CNS.
  • Recent findings highlight interactions between microglia and adaptive immune cells.

Purpose of the Study:

  • To explore the innate immune functions of microglia.
  • To detail how microglia interact with adaptive immune cells.
  • To understand microglia's role in CNS inflammation and immune surveillance.

Main Methods:

  • Review of microglia's innate immune properties.
  • Focus on pattern recognition receptors and inflammatory signaling.
  • Analysis of phagocytosis and microglia-adaptive immune cell interactions.

Main Results:

  • Microglia possess key innate immune characteristics.
  • Interactions with adaptive immunity modulate CNS surveillance.
  • These interactions are critical for initiating inflammatory or neuroprotective responses.

Conclusions:

  • Microglia's innate immunity and interactions with adaptive immune cells are central to CNS health and disease.
  • These processes dictate the balance between neuroprotection and neuroinflammation.
  • Understanding these mechanisms is vital for modulating immune-mediated CNS diseases.