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Related Concept Videos

Glial Cells01:04

Glial Cells

Overview
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...

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Related Experiment Video

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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Microglia in Glioma.

Stefano Garofalo1, Giuseppina D'Alessandro1, Cristina Limatola2

  • 1Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.

Advances in Neurobiology
|August 29, 2024
PubMed
Summary
This summary is machine-generated.

Microglia, a type of myeloid cell, interact with glioblastoma, the most aggressive brain tumor. These symbiotic interactions shape the brain tumor microenvironment, revealing diverse microglial functions.

Keywords:
Cold TumorGlioblastomaGlioma-associated microglia/macrophagesLymphocytesTumor Microenvironment

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Area of Science:

  • Neuroscience
  • Immunology
  • Oncology

Background:

  • Myeloid cells, particularly microglia, are key components of the brain tumor microenvironment.
  • Glioblastoma is the most common and aggressive primary brain tumor.
  • Understanding the interaction between microglia and glioblastoma is crucial for therapeutic development.

Purpose of the Study:

  • To summarize the current knowledge on the role of microglial cells in glioblastoma.
  • To elucidate the symbiotic interactions between microglia and glioblastoma cells.
  • To highlight the diverse functions of microglia in shaping the brain tumor microenvironment.

Main Methods:

  • Review of in vitro and in vivo studies.
  • Analysis of data from glioblastoma patients and glioma models.
  • Examination of microglial cell cross-talk with tumoral cells.

Main Results:

  • Microglia engage in symbiotic interactions with glioblastoma cells.
  • Microglial functions within the tumor microenvironment are heterogeneous.
  • These interactions significantly influence the brain tumor microenvironment.

Conclusions:

  • Microglia play a complex and multifaceted role in glioblastoma progression.
  • Targeting microglial functions presents a potential therapeutic strategy for glioblastoma.
  • Further research into microglial heterogeneity is warranted for effective treatment.