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Updated: May 5, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Automated Opt-Out Hepatitis C Testing to Reduce Missed Screening Opportunities in the Emergency Department
Heather Sperring1, Glorimar Ruiz-Mercado1, Brian J Yun1
1Heather Sperring and Glorimar Ruiz-Mercado are with the Department of Medicine, Section of Infectious Diseases, Boston Medical Center, Boston, MA. Brian J. Yun and Elissa M. Schechter-Perkins are with the Department of Emergency Medicine, Boston University Chobanian and Avedisian School of Medicine, Boston. David Twitchell and Bhavesh Shah are with the Department of Pharmacy, Boston Medical Center.
Abstract:
We evaluated the impact of implementing automated hepatitis C (HCV) opt-out screening in the emergency department of an urban, academic medical center with high HCV prevalence, in the context of a longstanding HCV opt-in screening model. We compared nine-month periods before and after implementation. HCV testing increased by 502%, and active HCV infection identification increased by 212%. Settings where there is great opportunity for HCV diagnosis, such as emergency department settings, should consider opt-out HCV screening models. (Am J Public Health. 2024;114(11):1228-1231. https://doi.org/10.2105/AJPH.2024.307783).
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