Tolerance of intravenously administered lipid in newborns

The tolerance for intravenously administered Intralipid in 262 premature and sick newborns was studied. The serum concentrations of triglycerides and of free fatty acids were determined during total parenteral nutrition including Intralipid in a maximum daily dose of 2 g/kg. A serum concentration of 1.5 mmol/l or higher was found in 270 out of 985 triglyceride determinations (27.4%). In the 262 infants serum triglyceride concentrations were found elevated once or more in 117 cases (44.7%). Serum free fatty acids concentrations were normal. A highly significant inverse correlation (p less than 0.001) between birth weight and triglyceride level was found. Elevated serum triglyceride concentrations were observed especially in preterm small-for-gestational-age infants.