Biocompatible polymer-based micro/nanorobots for theranostic translational applications

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Self-propelled micro/nanorobots (MNRs) are emerging as smart platforms for diagnostics and therapeutics.
• Polymer-based MNRs are gaining attention due to their biocompatibility and versatility for medical applications.

Purpose of the Study:

• To review multifunctional polymers used in MNRs.
• To explore polymer-based MNRs' characteristics, including biodegradability, motion control, and cargo capabilities.
• To summarize theranostic applications and translational challenges of polymer-based MNRs.

Main Methods:

• Literature review of polymer-based micro/nanorobots.
• Analysis of polymer properties relevant to MNRs (biodegradability, motion, loading, adhesion).
• Review of theranostic applications (bioimaging, biosensing, drug delivery, tissue engineering).

Main Results:

• Polymer-based MNRs exhibit versatile properties suitable for various medical applications.
• Key characteristics like biodegradability, motion control, and cargo delivery are crucial for translation.
• Applications span bioimaging, biosensing, drug delivery, and tissue engineering.

Conclusions:

• Polymer-based MNRs show significant potential for clinical translation in diagnostics and therapeutics.
• Addressing challenges in biodegradability, motion control, and targeted delivery is essential for future development.
• This review provides insights into advancing polymeric MNRs for clinical applications.