Agglutination of an EDTA blood sample caused by an EDTA-dependent panagglutinin

A novel example of an EDTA-dependent panagglutinin is described. A blood sample drawn into EDTA for a routine hematologic workup demonstrated strong agglutination due to EDTA-dependent panagglutinins. Previous examples have been detected because of discrepant ABO results. This is the first report of an EDTA-dependent panagglutinin that caused agglutination in the EDTA sample collection tube and a false positive direct antiglobulin test.