Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

398
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
398
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

926
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
926
What is the Immune System?01:38

What is the Immune System?

110.9K
Overview
110.9K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

3.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.7K
Humoral Immune Responses01:36

Humoral Immune Responses

72.3K
Overview
72.3K
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.3K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunodeficiency-autoimmunity syndromes.

Autoimmunity reviews·2026
Same author

Corrigendum to "Antibodies to expanded virus antigen panels show elevated diagnostic sensitivities in multiple sclerosis and optic neuritis" [Immunol. Lett. 254 (2023) 54-64].

Immunology letters·2025
Same author

Letter in reply.

Journal of the neurological sciences·2025
Same author

Native structure of the monoclonal therapeutic CD20 antibody ocrelizumab.

Biochimica et biophysica acta. Proteins and proteomics·2025
Same author

Virus-specific antibody responses in multiple sclerosis patients treated with Ocrevus.

Journal of the neurological sciences·2025
Same author

Virus-specific antibody responses in severe acute respiratory syndrome coronavirus 2-infected and vaccinated individuals.

Immunology letters·2025
Same journal

Decoding gut microbiome alterations in celiac disease: Implications for pathogenesis and treatment.

Autoimmunity reviews·2026
Same journal

Rethinking immunosuppression in limited cutaneous systemic sclerosis. The lcSSc conundrum; pros and cons for a timely immunosuppressive treatment.

Autoimmunity reviews·2026
Same journal

Kidney failure in patients with ANCA-associated vasculitis: A systematic review of outcomes.

Autoimmunity reviews·2026
Same journal

The role of antimicrobial peptides in rheumatoid arthritis: From mucosal predisposition to chronic synovitis.

Autoimmunity reviews·2026
Same journal

The role of short-chain fatty acids as key mediators of gut microbiota - host crosstalk in thyroid diseases.

Autoimmunity reviews·2026
Same journal

Intermittent hydrarthrosis (periodic synoviosis): A narrative review.

Autoimmunity reviews·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2025

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
09:42

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

Published on: June 7, 2017

11.4K

Auto-immuno-deficiency syndromes.

Gunnar Houen1

  • 1Department of Neurology and Translational Research Center (TRACE), Rigshospitalet, Nordstjernevej 42, DK-2600 Glostrup, Denmark; Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense, Denmark.

Autoimmunity Reviews
|August 29, 2024
PubMed
Summary
This summary is machine-generated.

Autoimmune diseases may be understood as auto-immuno-deficiency syndromes (AIdeSs), resulting from genetic factors and environmental triggers like infections. This concept integrates knowledge on immune deficiencies and chronic infections in disease development.

Keywords:
Autoimmune polyendocrine syndromeAutoimmunityAutoimmunodeficiency syndromeDermatomyositisDiabetes type 1Graves' diseaseImmunodeficiencyInfectionsMultiple sclerosisRheumatoid arthritisSjøgren's syndromeSystemic lupus erythematosus

More Related Videos

Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

12.3K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K

Related Experiment Videos

Last Updated: Jun 14, 2025

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue
09:42

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

Published on: June 7, 2017

11.4K
Isolation of Double Negative αβ T Cells from the Kidney
06:56

Isolation of Double Negative αβ T Cells from the Kidney

Published on: May 16, 2014

12.3K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.4K

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • Autoimmune diseases are diverse with overlapping symptoms, traditionally classified as systemic or organ-directed.
  • Existing theories include defective self-recognition, molecular mimicry, and bystander activation.
  • Genetic predisposition and environmental factors, such as infections, are recognized contributors.

Purpose of the Study:

  • To review the interplay of genetic factors and chronic infections in autoimmune diseases.
  • To propose a unifying concept of auto-immuno-deficiency syndromes (AIdeSs).
  • To integrate current knowledge on the development of autoimmune conditions.

Main Methods:

  • Literature review integrating genetic and environmental factors in autoimmune diseases.
  • Analysis of the role of immuno-phenotypes and infections.
  • Exemplification of the auto-immuno-deficiency syndromes (AIdeSs) concept.

Main Results:

  • Genetic factors include antigen presentation molecules (MHC I/II) and immune signaling molecules (immuno-phenotypes).
  • Infections, particularly Epstein-Barr virus, are significant environmental triggers.
  • Autoimmune diseases can be conceptualized as AIdeSs, linking immune deficiencies with chronic infections.

Conclusions:

  • Autoimmune diseases result from a complex interplay between genetic predisposition and environmental factors.
  • The concept of AIdeSs provides a framework for understanding the contribution of immune deficiencies and chronic infections.
  • Further research into AIdeSs may elucidate disease mechanisms and inform therapeutic strategies.