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Stability of cytarabine in a parenteral nutrient solution
American Journal of Hospital Pharmacy
|March 1, 1985
Summary
Cytarabine (also known as Ara-C) demonstrated stability in a common parenteral nutrient solution for pediatric patients. This chemotherapy drug maintained its concentration for at least 48 hours when stored at 8 and 25 degrees C.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Drug Stability
Background:
- Parenteral nutrition is crucial for pediatric patients unable to consume food orally.
- Cytarabine is a vital chemotherapeutic agent used in treating various cancers.
- Ensuring the stability of cytarabine in nutrient solutions is critical for effective treatment.
Purpose of the Study:
- To evaluate the stability of cytarabine in a standard parenteral nutrient solution.
- To determine the optimal storage conditions and duration for cytarabine admixtures.
Main Methods:
- Cytarabine was added to a parenteral nutrient solution at a concentration of 50 micrograms/mL.
- Samples were stored at two temperatures (8°C and 25°C).
- High-performance liquid chromatography (HPLC) was used to quantify cytarabine concentration over 96 hours, alongside pH and visual inspections.
Main Results:
- Cytarabine concentration remained between 90-104.4% of the initial concentration throughout the 96-hour study period.
- No significant changes in pH, particulate matter, or color were observed.
- Cytarabine was found to be stable for at least 48 hours under the tested conditions.
Conclusions:
- Cytarabine at 50 micrograms/mL is stable in the studied parenteral nutrient solution for at least 48 hours.
- The findings support the co-administration and storage of cytarabine with this parenteral solution.
- This stability data is essential for safe and effective pediatric cancer treatment protocols.