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Serum and glucocorticoid-regulated kinase 1 (SGK1) as an emerging therapeutic target for cardiac diseases

Fatemeh Yarmohammadi1, Gholamreza Karimi2

  • 1Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Pharmacological Research
|August 29, 2024
PubMed

Insights

Serum- and glucocorticoid-inducible kinase 1 (SGK1) is linked to heart disease, impacting cardiac hypertrophy and fibrosis. Understanding SGK1 signaling pathways is crucial for developing new treatments for cardiovascular conditions.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • Cardiac diseases are a major global health burden, causing significant morbidity and mortality.
  • Serum- and glucocorticoid-inducible kinase 1 (SGK1) is a key regulator of cellular processes like survival and stress response.
  • Dysregulation of SGK1 activity is implicated in various pathological conditions.

Purpose of the Study:

  • To review the role of SGK1 in the development of heart disease.
  • To explore the signaling pathways involving SGK1 in cardiovascular conditions.
  • To highlight the association between SGK1 and cardiac hypertrophy and fibrosis.

Main Methods:

  • Literature review of existing research on SGK1 and cardiac diseases.
  • Analysis of signaling pathways, including SGK1/NF-κB and PI3K/SGK1.
  • Examination of SGK1's involvement in cellular processes relevant to heart conditions.

Main Results:

  • SGK1 plays a significant role in cardiac hypertrophy and fibrosis.
  • Alterations in SGK1 activity are associated with the progression of heart disease.
  • Key signaling pathways like SGK1/NF-κB and PI3K/SGK1 are involved in SGK1's cardiac functions.

Conclusions:

  • SGK1 is a critical factor in the pathogenesis of cardiac diseases.
  • Targeting SGK1 signaling pathways may offer therapeutic strategies for heart conditions.
  • Further research into SGK1's role can advance cardiovascular disease management.

Keywords:
CardiopathologicHippo pathwayIon channelsNLRP3SGK1

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