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Related Concept Videos

Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

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Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

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Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
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Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
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Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

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An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
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Related Experiment Video

Updated: Jun 14, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
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Systematic Review and Meta-analysis: The Three-year Post-colonoscopy Colorectal Cancer Rate as per the World

Rawen Kader1, Andreas V Hadjinicolaou2, Nicholas E Burr3

  • 1Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London (UCL), London, United Kingdom.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|August 29, 2024
PubMed
Summary

The post-colonoscopy colorectal cancer-3yr rate (PCCRC-3yr) in the Western World was 7.5% and has decreased over time. Further research is needed to understand PCCRCs in high-risk individuals.

Keywords:
ColonoscopyColorectal CancerPost-colonoscopy Colorectal Cancer

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Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • The World Endoscopy Organization (WEO) established standardized methods in 2018 for calculating post-colonoscopy colorectal cancer-3yr rates (PCCRC-3yr).
  • This study aimed to assess global PCCRC-3yr rates using the WEO methodology.
  • It also investigated changes in PCCRC-3yr over time and identified associated risk factors.

Purpose of the Study:

  • To calculate the pooled Western World PCCRC-3yr using the WEO methodology.
  • To analyze the temporal trends of PCCRC-3yr.
  • To determine the association between specific risk factors and PCCRC occurrences.

Main Methods:

  • A systematic review of databases was conducted from inception until January 2024.
  • Studies strictly adhering to the WEO methodology for PCCRC-3yr calculation were included.
  • Pooled PCCRC-3yr rates and odds ratios for risk factor subgroups were calculated.

Main Results:

  • Eight studies from Western Europe and North America, including 220,106 colorectal cancers (CRCs) and 18,148 PCCRCs (2002-2017), met the WEO criteria.
  • The pooled Western World PCCRC-3yr was 7.5% (95% CI, 6.4%-8.7%).
  • PCCRC-3yr significantly decreased from 7.9% in 2006 to 6.7% in 2012.
  • Higher PCCRC-3yr rates were observed in individuals with inflammatory bowel disease, prior CRC, proximal CRC, diverticular disease, and in females.

Conclusions:

  • The Western World PCCRC-3yr, calculated using the WEO methodology, is 7.5% and shows a reassuring downward trend.
  • Further investigation is necessary to elucidate the causes of PCCRCs, particularly in high-risk populations.
  • A WEO methodology checklist was developed to promote standardization in future PCCRC-3yr studies.