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Updated: Jun 14, 2025
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Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
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Chronic thromboembolic pulmonary disease.
Nick H Kim1, Andrea M D'Armini2, Marion Delcroix3
1Division of Pulmonary, Critical Care, and Sleep Medicine, University of California San Diego, La Jolla, CA, USA.
The European Respiratory Journal
|August 29, 2024
Summary
Chronic thromboembolic pulmonary hypertension (CTEPH) is a treatable condition often diagnosed late. Prompt evaluation and multidisciplinary care, including mechanical therapies, significantly improve patient survival rates.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Vascular Surgery
Background:
- Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious complication of pulmonary embolism.
- It results from unresolved clots causing mechanical obstruction and microvascular disease, increasing pulmonary vascular resistance.
- Delayed diagnosis is common, hindering timely and effective treatment.
Purpose of the Study:
- To highlight the diagnostic challenges and treatment strategies for CTEPH.
- To emphasize the importance of expert centers and multidisciplinary decision-making.
- To review the efficacy of current therapeutic interventions.
Main Methods:
- Review of diagnostic modalities, focusing on high-quality imaging.
- Assessment of patient operability for surgical or interventional procedures.
- Evaluation of outcomes associated with various treatment approaches.
Main Results:
- Accurate diagnosis is often delayed, impacting treatment planning.
- Mechanical therapies, including pulmonary endarterectomy and balloon pulmonary angioplasty, offer the best symptom and survival improvements.
- Multimodal therapies achieve excellent outcomes, with 3-year survival exceeding 90%.
Conclusions:
- Early and accurate diagnosis of CTEPH is crucial.
- Referral to expert centers for multidisciplinary evaluation is essential for optimal management.
- Advanced treatment strategies, particularly mechanical therapies, lead to significantly improved long-term survival in CTEPH patients.
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