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Related Experiment Video

Updated: Jun 14, 2025

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing

Published on: November 17, 2023

Healing wounds with plasma-activated hydrogel therapy.

Sumyea Sabrin¹, Sung-Ha Hong¹, Debabrata K Karmokar²

¹Future Industries Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia.

Trends in Biotechnology

|August 29, 2024

Summary

Plasma-activated hydrogel therapy (PAHT) offers a novel approach to combat chronic wound infections. This innovative treatment uses cold atmospheric plasma to activate hydrogels, promoting healing and decontamination for potential community-based wound care.

Keywords:

autonomous systems chronic wounds cold atmospheric plasma (CAP)hydrogel medical technology plasma medicine plasma-activated hydrogel therapy (PAHT)wound dressing

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Area of Science:

Biomedical Engineering
Materials Science
Infectious Disease Management

Background:

Chronic wound infections represent a growing global healthcare challenge requiring novel therapeutic strategies.
Current treatments face limitations in effectively decontaminating wounds and promoting optimal healing.
Plasma-activated hydrogel therapy (PAHT) emerges as a promising innovation in this field.

Purpose of the Study:

To describe plasma-activated hydrogel therapy (PAHT) for chronic wound treatment.
To review current research and identify challenges in translating PAHT for medical applications.
To present a blueprint for an autonomous PAHT system for community-based wound management.

Main Methods:

Activation of hydrogels using cold atmospheric pressure plasma.
Introduction of reactive oxygen and nitrogen species onto hydrogel surfaces.
Evaluation of decontamination efficacy and wound healing promotion.

Main Results:

PAHT demonstrates potential for decontaminating chronic wound infections.
The therapy shows promise in promoting wound healing, both as a standalone treatment and in combination therapies.
Research is ongoing to overcome challenges in clinical translation.

Conclusions:

PAHT is a viable strategy for managing chronic wound infections and enhancing healing.
Further research and development are crucial for the successful clinical implementation of PAHT.
An autonomous PAHT system could revolutionize wound care by enabling community-based treatment.