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Interdomain-linkers control conformational transitions in the SLC23 elevator transporter UraA

Benedikt T Kuhn1,2, Jonathan Zöller3, Iwan Zimmermann4

  • 1Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Frankfurt am Main, Germany.

Nature Communications
|August 29, 2024
PubMed
Summary

Interdomain-linkers in SLC23 transporters are not just flexible tethers but crucial regulators. They dictate conformational changes, influencing substrate affinity and transport rate for essential nucleobase and ascorbate uptake.

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