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Updated: Jun 14, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

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Published on: July 31, 2019

Spaceflight alters host-gut microbiota interactions.

E Gonzalez^1,2, M D Lee^3,4, B T Tierney^5,6

¹Microbiome Unit, Canadian Centre for Computational Genomics, Department of Human Genetics, McGill University, Montréal, Canada.

NPJ Biofilms and Microbiomes

|August 29, 2024

Summary

This summary is machine-generated.

Spaceflight alters the gut microbiome in mice, reducing beneficial bacteria. These changes in host-gut interactions contribute to spaceflight-induced diseases and impact long-duration spaceflight feasibility.

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Published on: July 9, 2021

Area of Science:

Microbiology
Space Biology
Genomics

Background:

Spaceflight induces physiological changes in mammals, including liver disease, insulin resistance, osteopenia, and myopathy.
The role of the gut microbiome in these spaceflight-induced pathologies is not fully understood.

Purpose of the Study:

To investigate the impact of spaceflight on the murine gut microbiota and host gene expression.
To elucidate host-microbiota interactions during spaceflight.

Main Methods:

Multiomics analysis of murine gut microbiota and host gene expression in the colon and liver.
Metagenomic sequencing and functional prediction after 29 and 56 days of spaceflight.

Main Results:

Significant alterations in 44 microbiome species, with reductions in bile acid and butyrate-metabolizing bacteria.
Functional predictions showed enrichment of genes related to fatty acid and bile acid metabolism, extracellular matrix interactions, and antibiotic resistance.
Host gene expression revealed changes in bile acid and energy metabolism, and immune suppression.

Conclusions:

Host-gut microbiome interactions are implicated in spaceflight-associated pathologies.
These interactions may significantly influence human health and the feasibility of long-duration spaceflight.