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[Lambl's excrescences].

R Loire, A Tabib, G Saint-Pierre

    Archives Des Maladies Du Coeur Et Des Vaisseaux
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Lambl's excrescences (LE) are small cardiac valve outgrowths. Histological analysis revealed two forms, suggesting local factors, not systemic circulation, cause these mobile or incorporated lesions.

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    Area of Science:

    • Cardiovascular Pathology
    • Histopathology

    Context:

    • Lambl's excrescences (LE), initially described in 1856, are increasingly detected via echocardiography.
    • These filiform outgrowths originate from the free border of cardiac valves.

    Purpose:

    • To define the anatomy and histology of Lambl's excrescences.
    • To investigate the pathogenic mechanisms of LE.

    Summary:

    • Analysis of 30 cases revealed LE on aortic, mitral, tricuspid, and pulmonary valves, ranging from 2 to 12 mm.
    • Histologically, two forms were identified: mobile, pedunculated lesions and lesions incorporated within the valve structure.
    • Pathogenic mechanisms proposed include endothelial folding, fibrin deposition on ulcerated zones, and incorporation of edema and red blood cells.

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    Impact:

    • Provides detailed anatomical and histological characterization of Lambl's excrescences.
    • Suggests local valvular conditions, rather than systemic circulatory changes, are primary etiological factors.
    • Differentiates LE from non-bacterial thrombotic endocarditis, clarifying their potential lack of association.