Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Secondary epileptogenesis in man.

F Morrell

    Archives of Neurology
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Secondary epileptogenesis, the development of new seizure foci, was proven in 34% of human brain tumor patients. A new test predicts surgical outcomes for epilepsy treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Surgical resection for intractable epilepsy in "double cortex" syndrome yields inadequate results.

    Epilepsia·2001
    Same author

    From mirror focus to secondary epileptogenesis in man: an historical review.

    Advances in neurology·1999
    Same author

    Multiple subpial transection.

    Advances in neurology·1999
    Same author

    Direct intraoperative recordings from the hippocampal formation: relation with quantitative volumetric MRI.

    Electroencephalography and clinical neurophysiology. Supplement·1999
    Same author

    Alzheimer's disease: in vivo detection of differential vulnerability of brain regions.

    Neurobiology of aging·1997
    Same author

    Cholinergic synapses in human cerebral cortex: an ultrastructural study in serial sections.

    Experimental neurology·1997

    Area of Science:

    • Neurology
    • Epileptology
    • Neuroscience

    Background:

    • Secondary epileptogenesis is challenging to demonstrate in humans.
    • Existing theories often attribute new seizure foci to multiple primary causes or progressive disease.
    • Cerebral tumors present a unique model due to the low probability of multiple primary lesions.

    Purpose of the Study:

    • To investigate the existence and characteristics of secondary epileptogenesis in human epilepsy patients with cerebral tumors.
    • To analyze clinical, electrophysiologic, and pharmacologic data for evidence of secondary epileptogenesis.
    • To describe the stages of secondary epileptogenesis in humans and develop a predictive pharmacologic test.

    Main Methods:

    • Review of a clinical series of cerebral tumor patients presenting with epilepsy.

    Related Experiment Videos

  • Analysis of clinical, electrophysiologic, and pharmacologic data.
  • Development and application of a pharmacologic test to differentiate stages of secondary epileptogenesis.

    • Main Results:

    • Evidence of secondary epileptogenesis was found in 34% of patients with cerebral tumors.
    • The three previously documented stages of secondary epileptogenesis in animals were demonstrated in humans.
    • A pharmacologic test successfully distinguished between reversible and irreversible stages.

    Conclusions:

    • Secondary epileptogenesis is a demonstrable phenomenon in human focal epilepsy, particularly in the context of cerebral tumors.
    • The findings support the existence of distinct stages in the development of secondary epileptic foci.
    • The described pharmacologic test can predict the efficacy of primary focus removal in epilepsy surgery.