Identification of clinical prognosis features and significant DNA methylation regulation in pineoblastoma
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View abstract on PubMed
Summary
This summary is machine-generated.Pineoblastoma prognosis is linked to patient sex, age, and radiotherapy. Aberrations in RAS and MAPK pathways may influence outcomes, suggesting targeted therapies like dasatinib and trametinib could improve survival.
Area Of Science
- Oncology
- Genetics
- Bioinformatics
Background
- Pineoblastoma (PB) presents significant clinical management challenges due to the absence of specific therapeutic regimens.
- Identifying prognostic factors and therapeutic targets is crucial for improving patient outcomes.
Purpose Of The Study
- To identify independent prognostic factors for overall survival (OS) in pineoblastoma patients.
- To explore potential therapeutic targets by analyzing DNA methylation patterns and associated signaling pathways.
Main Methods
- Utilized SEER database (2000-2019) for clinical data and survival analysis (Cox regression, nomogram).
- Analyzed DNA methylation data from GEO datasets (GSE133801, GSE215240) using bioinformatics approaches.
- Performed Gene Ontology (GO) and KEGG pathway enrichment analyses on aberrantly methylated genes.
Main Results
- Male gender, age < 3 years, and lack of radiotherapy were associated with poorer OS in 383 PB patients.
- Multivariate analysis confirmed sex, age, and radiotherapy as independent prognostic factors.
- DNA methylation analysis revealed tumor hypomethylation, particularly in promoter regions, linked to embryonic development and MAPK/RAS signaling pathways.
Conclusions
- Pineoblastoma prognosis is significantly influenced by sex, age at diagnosis, and radiotherapy.
- Aberrations in RAS and MAPK signaling pathways are implicated in PB pathogenesis.
- Dasatinib and trametinib show potential as targeted therapies for pineoblastoma.
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