[Peripheral blood lymphocyte subsets are associated with the prognosis of prostate cancer]
1Department of Urology, Huai'an First Hospital Affiliated to Nanjing Medical University, Huai'an, Jiangsu 223300, China .
Objective:
To explore the relationship between peripheral lymphocyte subsets and the survival of PCa patients.
Methods:
Using the Kaplan-Meier curve and log-rank test, we compared the overall survival (OS) and progression-free survival (PFS) of 100 PCa patients with different levels of lymphocytes. Meanwhile, we investigated the prognostic factors by univariate and multivariate Cox regression analyses, and counted the peripheral lymphocyte subsets by flow cytometry.
Results:
Both OS and PFS were significantly prolonged in the PCa patients with high levels of lymphocytes (≥747/μl), CD3+T cells (≥528/μl), CD4+T cells (≥315/μl), CD8+T cells (≥226/μl), B cells (≥105/μl) and NK cells (≥168/μl)(P < 0.001). Univariate and multivariate Cox regression analyses indicated that CD4+T cells ≤ 315/μl was an independent factor for the poor prognosis of PCa (HR=12.58, 95% CI: 3.00－52.73).
Conclusion:
Decreased absolute count of peripheral lymphocyte subsets is associated with the poor prognosis of PCa.
