Related Experiment Video
Updated: May 5, 2026
12:19
ReAsH/FlAsH Labeling and Image Analysis of Tetracysteine Sensor Proteins in Cells
Published on: August 31, 2011
17.3K
Animal amino acid sensor - A review
Yongding Ke1, Xinyu Peng1, Chengchuang Song1
1School of Life Science, Jiangsu Normal University, Jiangsu 221116, China.
Animal Bioscience
|August 30, 2024
Summary
Amino acids are crucial for cell growth and are sensed by the mammalian target of rapamycin complex 1 (mTORC1). This review explores amino acid sensors and their role in livestock development.
Area of Science:
- Biochemistry
- Cell Biology
- Animal Science
Background:
- Amino acids are essential for cell growth and metabolism.
- The mammalian target of rapamycin complex 1 (mTORC1) integrates amino acid signals.
- Molecular mechanisms of amino acid sensing by mTORC1 are not fully understood.
Purpose of the Study:
- To review identified amino acid sensors.
- To describe their structures and biological functions.
- To evaluate their role in livestock development.
Main Methods:
- Literature review of existing research on amino acid sensing.
- Analysis of structural and functional data of identified sensors.
- Evaluation of potential applications in livestock production.
Main Results:
- Several specific amino acid sensors have been identified.
- These sensors relay signals to mTORC1 indirectly.
- The identified sensors have diverse biological functions.
Conclusions:
- Understanding amino acid sensors is key to elucidating mTORC1 regulation.
- These sensors may offer targets for improving livestock development and production.
Related Concept Videos
03:42Amino acids
73.1K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible...
73.1K
01:15Mass Spectrometry of Amines
3.9K
In mass spectroscopy, amines undergo fragmentation to give parent ions with odd molecule weights. This observed mass spectrum follows the nitrogen rule; a molecule with an odd number of nitrogen atoms produces a molecular ion with an odd molecular weight. Amines undergo fragmentation through α cleavage, producing nitrogen-containing cations—iminium ions—and alkyl radicals. Mass spectra of aromatic and cyclic aliphatic amines exhibit strong molecular ion peaks, but acyclic...
3.9K
01:18Amino Acid Catabolism
1.8K
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
1.8K
01:29Amino Acid Biosynthetic Pathways
1.8K
Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
1.8K