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Intranasal corticosteroid users in The Netherlands: A drug utilization study.

Corine Rollema1,2, Eric N Van Roon1,2, Nynke C C M Schuiling-Veninga2

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The Journal of Allergy and Clinical Immunology. Global
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Summary

Intranasal corticosteroid (INC) use varies widely across age groups and usage patterns. Understanding these patterns and comedication helps tailor instructions for better INC treatment adherence and efficacy.

Keywords:
Intranasal corticosteroidsadministration techniquecharacteristicscomedicationpatient-tailored administration instructionsprescription data

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Area of Science:

  • Pharmacology
  • Allergy and Immunology
  • Public Health

Background:

  • Patient-tailored instructions for intranasal corticosteroid (INC) administration require understanding user characteristics and comedication.
  • Previous research has not fully elucidated the prevalence, incidence, and patterns of INC use and concurrent medications.

Purpose of the Study:

  • To investigate the prevalence and incidence of INC use.
  • To analyze patterns of INC use over time (previous years).
  • To identify common comedications used alongside INCs.

Main Methods:

  • Retrospective analysis of INC prescriptions from the Dutch InterAction Database (2015-2019).
  • Stratification of prevalence and incidence rates by age and sex.
  • Analysis of INC prescription history and concurrent medication use.

Main Results:

  • In 2019, 75,048 individuals received 172,563 INC prescriptions, with prevalence and incidence rates of 68.9 and 25.6 per 1000 individuals, respectively.
  • INC use spans all age groups, with varied patterns including new, intermittent, and continuous users.
  • Common comedications included inhalers (28%), systemic antihistamines (29%), ocular medications (9%), and other corticosteroids (2-16%).

Conclusions:

  • Findings provide insights for developing patient-tailored INC instructions to improve adherence and efficacy.
  • Understanding comedication patterns can enhance the evaluation of INC administration techniques.
  • A more personalized approach to INC therapy may lead to improved treatment outcomes.