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Related Experiment Video

Updated: Jun 14, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

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Contactless magnetically responsive injectable hydrogel for aligned tissue regeneration.

Arianna Rossi1,2, Franco Furlani1, Giada Bassi1,3

  • 1Institute of Science, Technology and Sustainability for Ceramics, National Research Council of Italy. Via Granarolo 64, 48018. Faenza, Italy.

Materials Today. Bio
|August 30, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a novel injectable hydrogel that uses magnetic fields to align cells, offering a non-invasive method for tissue regeneration. The biomaterial promotes cell growth and healing, showing promise for treating aligned human tissues.

Keywords:
Anisotropic architectureMagnetic biomaterialMinimally invasive surgeryRegenerative medicineResponsive hydrogel

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Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Cellular alignment is crucial for human tissues like skeletal muscle and spinal cord.
  • Existing 3D-aligned scaffolds often require invasive surgery.
  • Injectable hydrogels offer a minimally invasive alternative for tissue regeneration.

Purpose of the Study:

  • To develop a magnetically responsive, injectable hydrogel for non-invasive tissue regeneration.
  • To create an anisotropic architecture within the hydrogel using magnetic fields.
  • To evaluate the biocompatibility and efficacy of the hydrogel for tissue repair.

Main Methods:

  • Engineered a hydrogel from gellan gum, hyaluronic acid, collagen, and magnetic nanoparticles (MNPs).
  • Formed magnetic collagen bundles (MCollB) for magnetic orientation control.
  • Assessed hydrogel mechanical properties, *in vitro* cell responses, and *in vivo* biocompatibility and injectability.

Main Results:

  • Achieved anisotropic hydrogel architecture via magnetic field-guided MCollB alignment.
  • Hydrogel mechanical properties mimic human soft tissues.
  • *In vitro* studies showed no toxicity, reduced inflammation, enhanced fibroblast proliferation, and activated macrophages.
  • *In vivo* studies confirmed biocompatibility, successful injection, and rapid *in situ* gelation.

Conclusions:

  • The developed hydrogel provides a biomimetic, magnetically controllable, and injectable solution for tissue regeneration.
  • This minimally invasive approach shows significant potential for treating conditions affecting aligned human tissues.
  • The rapid gelation and biocompatibility make it a promising therapeutic agent.