Mechanisms of crosstalk between the oropharyngeal microbiome and human papillomavirus in oropharyngeal carcinogenesis: a mini review
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View abstract on PubMed
Summary
This summary is machine-generated.Human papillomavirus (HPV)-positive oropharyngeal cancers are increasing. This review explores the oropharyngeal microbiome and how HPV interacts with microbes, impacting cancer development.
Area Of Science
- Oncology
- Microbiology
- Virology
Background
- Head and neck squamous cell carcinoma (HNSCC) is a global health concern.
- Human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) represents a growing subset of these cancers.
- While HPV infection is a known risk factor, it is insufficient to cause cancer, suggesting other factors are involved.
Purpose Of The Study
- To review the current understanding of the oropharyngeal microbiome in HPV-positive OPSCC.
- To investigate compositional shifts within the oropharyngeal microbiome associated with HPV-positive OPSCC.
- To explore potential mechanisms of interaction (crosstalk) between HPV and microorganisms in the oropharynx.
Main Methods
- Literature review of studies on the oropharyngeal microbiome.
- Analysis of research on HPV-positive oropharyngeal squamous cell carcinoma.
- Synthesis of findings on HPV-microbiome interactions.
Main Results
- The oropharyngeal microbiome composition is altered in HPV-positive OPSCC.
- Specific microorganisms may interact with HPV, influencing cancer development.
- The precise mechanisms of this HPV-microbiome crosstalk remain largely unelucidated.
Conclusions
- Understanding the oropharyngeal microbiome and its interaction with HPV is crucial for HPV-positive OPSCC.
- Further research is needed to elucidate the mechanisms of HPV-microbiome crosstalk.
- These interactions may offer novel targets for cancer prevention and treatment strategies.
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