The association between rheumatoid arthritis and left ventricular diastolic dysfunction: pathogenesis, predictors and...

Area of Science:

• Cardiology
• Rheumatology
• Immunology

Background:

• Left ventricular diastolic dysfunction (LVDD) is central to heart failure with preserved ejection fraction (HFpEF).
• Low-grade inflammation is a primary driver of LVDD.
• Rheumatoid arthritis (RA) is a systemic inflammatory condition with increased LVDD risk in affected individuals.

Purpose of the Study:

• To review the pathogenesis of LVDD in RA patients.
• To identify predictors of LVDD in the context of RA.
• To summarize current management strategies for LVDD in RA.

Main Methods:

• Literature review of epidemiological studies and clinical research.
• Analysis of the role of systemic inflammation in LVDD development.
• Synthesis of data on risk factors and therapeutic approaches.

Main Results:

• Chronic inflammation in RA contributes to the development of LVDD.
• Specific predictors for LVDD in RA patients are being identified.
• Management strategies require addressing both RA and LVDD components.

Conclusions:

• RA significantly increases the risk of LVDD, impacting HFpEF.
• Understanding the inflammatory link is crucial for LVDD prevention and treatment in RA.
• Multifaceted management approaches are necessary for patients with both conditions.