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[Factors affecting the postoperative prognosis of penile cancer]

  • 0School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong 261041, China.
Zhonghua Nan Ke Xue = National Journal of Andrology +

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August 30, 2024

|

August 30, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Preoperative neutrophil-to-lymphocyte ratio (NLR) is a key predictor of penile cancer survival. Higher NLR indicates a poorer prognosis, alongside factors like age and tumor stage.

Area Of Science

  • Oncology
  • Urology
  • Medical Statistics

Context

  • Penile cancer prognosis significantly impacts patient outcomes.
  • Identifying reliable prognostic factors is crucial for treatment planning.

Purpose

  • To identify independent risk factors influencing cancer-specific survival (CSS) in penile cancer patients post-surgery.
  • To evaluate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and other clinical parameters.

Summary

  • This retrospective study analyzed 112 penile cancer cases, revealing 1-, 3-, and 5-year CSS rates of 78.2%, 66.1%, and 63.7%.
  • High preoperative neutrophil-to-lymphocyte ratio (NLR) was identified as an independent risk factor for decreased CSS (HR=2.6, P=0.043).
  • Other poor prognostic indicators include older age, manual labor occupation, lower education, low lymphocyte-to-monocyte ratio (LMR), high fibrinogen (FIB), advanced tumor stage, and poor differentiation.

Impact

  • Preoperative NLR assessment can aid in stratifying penile cancer patients by risk.
  • Findings may inform personalized treatment strategies and improve patient counseling.
  • Highlights the importance of considering inflammation markers in cancer prognosis.

Keywords:

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