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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

Updated: Jun 14, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
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miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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[Inflammatory factors and prostate cancer: Two-sample Mendelian randomization analysis].

Yin Zeng1, Gan-Lin Zhang1, Jun Guo2

  • 1Beijing Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing 100010, China.

Zhonghua Nan Ke Xue = National Journal of Andrology
|August 30, 2024
PubMed
Summary

This study investigated inflammatory factors and prostate cancer (PCa) risk using Mendelian randomization. Interleukin-22 receptor A1 (IL-22RA1) and sulfotransferase 1A1 (ST1A1) were linked to increased PCa risk, while Chemokine ligand 11 (CXCL11) and interleukin 17 A (IL-17A) were linked to decreased risk.

Area of Science:

  • Genetics
  • Immunology
  • Oncology
Keywords:
inflammatory factors; prostate cancer; Mendelian randomization; sensitivity analysis ; single nucleotide polymorphism; Bayesian analysis

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