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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Application of Injectable Hydrogels as Delivery Systems in Osteoarthritis and Rheumatoid Arthritis.

Rong Zhu1, Hai-Yang Liao2, Yi-Chen Huang2

  • 1Department of Rheumatology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China.

British Journal of Hospital Medicine (London, England : 2005)
|August 30, 2024
PubMed
Summary

Injectable hydrogels offer a promising solution for arthritis treatment by delivering drugs directly to the joint. This approach improves drug retention and therapeutic effectiveness for osteoarthritis (OA) and rheumatoid arthritis (RA).

Keywords:
disease treatmentdrug deliveryinjectable hydrogelsosteoarthritisrheumatoid arthritis

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Area of Science:

  • Biomaterials Science
  • Rheumatology
  • Drug Delivery Systems

Background:

  • Osteoarthritis (OA) and rheumatoid arthritis (RA) are inflammatory joint diseases causing pain and functional loss.
  • Current oral and intravenous drug therapies for arthritis have limitations, including side effects and poor drug absorption.
  • Improved drug delivery methods are crucial for effective long-term arthritis management.

Purpose of the Study:

  • To review injectable hydrogels as advanced drug delivery systems for arthritis treatment.
  • To analyze the application of hydrogels in counteracting inflammation, degradation, and oxidative stress in OA and RA.
  • To explore hydrogel-based strategies for promoting joint cartilage regeneration.

Main Methods:

  • Review of existing literature on injectable hydrogels for arthritis.
  • Analysis of hydrogel properties, including immunogenicity, biodegradability, and biocompatibility.
  • Exploration of hydrogel mechanisms in managing inflammatory joint diseases.

Main Results:

  • Injectable hydrogels provide controlled and continuous drug release within the joint cavity.
  • Hydrogels enhance drug retention, improving therapeutic effectiveness for OA and RA.
  • Hydrogels demonstrate potential in mitigating inflammation, bone/cartilage degradation, and oxidative stress.

Conclusions:

  • Injectable hydrogels represent a significant advancement in drug delivery for arthritis.
  • These systems offer improved therapeutic outcomes by targeting the joint directly.
  • Further development of injectable hydrogels holds promise for enhanced OA and RA treatment and cartilage regeneration.