Related Experiment Video
Updated: Jun 16, 2025
07:34
Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
Published on: December 16, 2022
2.2K
The Clinical Impact of Time-restricted Eating on Cancer: A Systematic Review
Eleah J Stringer1,2,3, Rob W G Cloke1,4, Lindsay Van der Meer1,2,3
1Nursing and Allied Health Research and KT Department, BC Cancer, Vancouver, BC V5Z 1G1, Canada.
Nutrition Reviews
|August 30, 2024
Summary
Time-restricted eating (TRE) is feasible for cancer patients and may offer oncological benefits. This dietary intervention shows promise in improving quality of life and potentially reducing cancer markers.
Area of Science:
- Oncology
- Nutritional Science
- Metabolic Health
Background:
- Growing global cancer burden necessitates exploring dietary interventions.
- Pre-clinical studies suggest time-restricted eating (TRE) impacts metabolism and gut microbiome, potentially inhibiting carcinogenesis.
- Human studies on TRE in cancer are emerging, requiring synthesis of current evidence.
Purpose of the Study:
- To systematically evaluate the clinical and metabolomic effects of TRE in cancer patients.
- To compare TRE against ad libitum eating or alternative dietary patterns.
- To synthesize evidence from human studies on TRE for cancer.
Main Methods:
- Comprehensive literature search across multiple databases (MEDLINE, Embase, CINAHL, Cochrane, Web of Science, SCOPUS) up to January 2023.
- Inclusion of original study designs, protocols, and clinical trial registries focusing on intermittent fasting and cancer.
- Extraction, comparison, and critical analysis of data from 24 selected entries (8 articles, 2 abstracts, 1 protocol, 13 registries).
Main Results:
- High adherence rates (67-98%) to TRE observed in cancer patients.
- Improvements in quality of life reported in multiple studies.
- Preliminary evidence suggests TRE may reduce cancer markers (e.g., CEA), lower recurrence rates, and improve metabolic risk factors (BMI, adiposity, glucoregulation, inflammation) within 8 weeks.
Conclusions:
- Time-restricted eating (TRE) is a feasible and acceptable dietary intervention for individuals with cancer.
- Preliminary findings indicate potential oncological benefits associated with TRE.
- TRE demonstrates a positive impact on quality of life for cancer patients.
Related Concept Videos
02:59Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
01:21Cancer Survival Analysis
334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334
01:19Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
02:34Inhibition of Cdk Activity
4.7K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K