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Updated: Jun 14, 2025
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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
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Gastrointestinal Malignancy: Genetic Implications to Clinical Applications.
Hannah E Trembath1,2, Jen Jen Yeh1,2, Nicole E Lopez3,4
1Division of Colon and Rectal Surgery, Department of Surgery, University of California San Diego, 4303 La Jolla Village Drive Suite 2110, San Diego, CA, 92122, USA.
Cancer Treatment and Research
|August 30, 2024
Summary
Molecular genetics advances understanding of gastrointestinal (GI) cancers. This overview covers key genetic alterations, oncogenic pathways, and biomarkers for precision oncology, including targeted therapies and immunotherapies.
Area of Science:
- Oncology
- Molecular Genetics
- Gastroenterology
Background:
- Molecular genetics has transformed the understanding of gastrointestinal (GI) cancer pathogenesis and progression.
- Key genetic alterations drive tumorigenesis across GI cancer sites like GIST, colon, rectum, and pancreas.
Purpose of the Study:
- To provide a comprehensive overview of the molecular landscape of GI cancers.
- To emphasize critical oncogenic pathways and the role of molecular biomarkers.
- To discuss the integration of genomic profiling and precision oncology in GI cancer treatment.
Main Methods:
- Review of key genetic alterations (mutations, instability, epigenetic modifications) in GI tumorigenesis.
- Analysis of oncogenic pathways driving cancer development.
- Discussion of molecular biomarkers for prognosis and treatment selection.
Main Results:
- Identification of significant genetic alterations and oncogenic pathways across GI cancers.
- Demonstration of molecular biomarkers' utility in predicting outcomes and guiding therapy.
- Highlighting the increasing role of genomic profiling in clinical practice.
Conclusions:
- Molecular genetics provides critical insights into GI cancer development and progression.
- Genomic profiling and precision oncology are revolutionizing GI cancer treatment strategies.
- Targeted therapies and immunotherapies represent the future of GI cancer care.
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