Related Experiment Video
Updated: Jun 14, 2025
06:08
Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
Published on: February 7, 2014
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Enlarged Perivascular Spaces Are Independently Associated with High Pulse Wave Velocity: A Cross-Sectional Study
Yoshino Kinjo1,2, Naoki Saji2, Kenta Murotani3,4
1Department of Cardiovascular Medicine, Nephrology and Neurology, University of the Ryukyus Graduate School of Medicine, Nishihara-cho, Okinawa, Japan.
Journal of Alzheimer'S Disease : JAD
|August 30, 2024
Summary
High brachial-ankle pulse wave velocity (PWV) is linked to enlarged perivascular spaces in the basal ganglia, potentially worsening cognitive impairment in older adults.
Area of Science:
- Neuroscience
- Cardiovascular Science
- Gerontology
Background:
- Cerebral small vessel disease (SVD) and cognitive impairment are linked to pulse wave velocity (PWV).
- The association between brachial-ankle PWV and enlarged perivascular spaces (EPVS), a marker of SVD, is not well-established.
Purpose of the Study:
- To investigate the relationship between brachial-ankle PWV and the severity of EPVS in individuals without dementia.
- To explore the potential mediation of this relationship on cognitive function.
Main Methods:
- Cross-sectional study of 74 participants, assessing cognitive function, brachial-ankle PWV, and brain MRI.
- EPVS were quantified in the basal ganglia (BG-EPVS) and centrum semiovale (CSO-EPVS).
- Multivariable logistic regression and causal mediation analyses were employed.
Main Results:
- High brachial-ankle PWV and age were independently associated with increased BG-EPVS severity.
- Age, but not brachial-ankle PWV, was associated with CSO-EPVS severity.
- Brachial-ankle PWV had a significant indirect effect on mild cognitive impairment (MCI) mediated by BG-EPVS.
Conclusions:
- Brachial-ankle PWV is associated with the severity of basal ganglia enlarged perivascular spaces (BG-EPVS).
- Elevated PWV may contribute to cognitive decline by increasing cerebrovascular pulsatility, thereby exacerbating BG-EPVS.
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