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Related Experiment Video

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Rasch Measurement Theory (RMT) Analyses of the Huntington's Disease Everyday Functioning (Hi-DEF) to Evaluate Item

Jennifer Petrillo1, Ruta Sawant1, Emma Elliott2

  • 1Sage Therapeutics, Inc., Cambridge, MA, USA.

Journal of Huntington'S Disease
|August 30, 2024
PubMed
Summary

The Huntington's Disease Everyday Functioning (Hi-DEF) tool reliably measures cognitive impairment's daily impact in early stages. This patient-reported outcome (PRO) instrument is validated for use in Huntington's Disease research.

Keywords:
Hi-DEFHuntington’s diseaseactivities of daily livingexecutive functionpatient-reported outcomespsychometrics

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Area of Science:

  • Neurology
  • Psychometrics
  • Patient-Reported Outcomes

Background:

  • Huntington's Disease (HD) significantly impacts daily functioning due to cognitive impairment.
  • Existing measures may not adequately capture these effects in early-stage HD.
  • The Huntington's Disease Everyday Functioning (Hi-DEF) instrument was developed as a patient-reported outcome (PRO) to address this gap.

Purpose of the Study:

  • To psychometrically validate the Hi-DEF instrument.
  • To finalize the item content of the Hi-DEF for early-stage HD.
  • To assess the measurement properties of the Hi-DEF using Rasch Measurement Theory (RMT).

Main Methods:

  • A cross-sectional, observational psychometric validation study was conducted.
  • 151 individuals with early-stage HD participated across 9 US centers.
  • Rasch Measurement Theory (RMT) analysis was applied to a 47-item draft of the Hi-DEF and its subscales.

Main Results:

  • Seven items were removed, resulting in a 40-item Hi-DEF version.
  • The 40-item Hi-DEF demonstrated good psychometric properties, including reliability (Person Separation Index 0.92 for full scale).
  • Targeting, response scale ordering, item fit, and local independence were evaluated across subscales ('Home', 'At work', 'Driving', 'Communication').

Conclusions:

  • The Hi-DEF instrument is a reliable and valid PRO for assessing daily functioning impacted by cognitive impairment in early HD.
  • The study supports the psychometric integrity of the Hi-DEF.
  • Future research will focus on external validity and clinical trial utility.