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β-Adrenergic Agonist-Induced Lactic Acidosis: A Case Report
1Raymond R. Blush III is Clinical Assistant Professor, University of Michigan School of Nursing, Room 2304, 400 SNB N Ingalls, Ann Arbor, MI 48109 (rayblush@umich.edu).
AACN Advanced Critical Care
|August 30, 2024
Summary
Albuterol, a common asthma medication, can cause elevated lactate levels and acidosis, even as patients clinically improve. This case highlights the need to monitor lactate during intensive albuterol treatment for severe asthma exacerbations.
Area of Science:
- Emergency Medicine
- Pharmacology
- Critical Care
Background:
- Albuterol is a primary treatment for acute asthma exacerbations.
- Severe cases often involve sequential, high-dose albuterol administration.
- Hyperlactatemia and acidosis have multiple causes in acute dyspnea.
Purpose of the Study:
- To report a case of elevated lactate levels secondary to albuterol administration.
- To discuss potential causes of hyperlactatemia in asthma patients.
- To outline monitoring and management considerations for albuterol-induced hyperlactatemia.
Main Methods:
- Clinical case report presentation.
- Review of potential causes for elevated lactate.
- Discussion of beta-adrenergic agonist effects.
Main Results:
- A patient receiving intensive albuterol treatment for asthma showed rising lactate levels.
- Lactate levels increased despite clinical improvement in respiratory status.
- Albuterol administration was identified as a potential cause of hyperlactatemia.
Conclusions:
- Albuterol can be an underrecognized cause of hyperlactatemia and acidosis.
- Monitoring lactate levels in patients receiving intensive albuterol is crucial.
- Consideration of albuterol withdrawal may be necessary if lactate levels rise significantly.
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