CD19+CD73+ B cells infiltration indicates poor prognosis and unfavorable responses to immunotherapy in gastric cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated CD73+ B cells in gastric cancer (GC) correlate with poor survival and reduced immunotherapy response. These cells promote tumor growth by suppressing antitumor immunity and aiding CD8+ T cell exhaustion.
Area Of Science
- Immunology
- Oncology
- Cell Biology
Background
- Cluster of Differentiation 73 (CD73) is expressed on immune cells and influences antitumor immunity.
- CD73's role in gastric cancer (GC) and its specific function on B cells remain underexplored.
Purpose Of The Study
- To investigate the expression and functional mechanisms of CD73 on B cells in gastric cancer patients.
- To determine the prognostic and predictive significance of CD19+CD73+ B cells in GC.
Main Methods
- Dual immunohistochemistry staining in 390 GC patients.
- Flow cytometry analysis of fresh tumor and non-tumor tissues from 8 GC patients.
- Bioinformatics analysis of scRNA-seq data and immunofluorescence staining for B cell subtypes.
Main Results
- CD19+CD73+ B cell infiltration was higher in GC tissues than normal tissues.
- Increased CD19+CD73+ B cells correlated with poor overall survival and diminished neoadjuvant immunotherapy response.
- These cells represent a subset of regulatory B cells (Bregs) associated with adenosine metabolism, CD8+ T cell exhaustion, IL-10/TGFB1 production, and advanced GC stage.
Conclusions
- CD19+CD73+ B cells can serve as a prognostic indicator for GC clinical outcomes.
- These cells may predict poor responsiveness to neoadjuvant immunotherapy in GC patients.
- The association with CD8+ T cell exhaustion and immunosuppression underscores the tumor-promoting role of CD19+CD73+ B cells in GC.
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