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Updated: Jun 14, 2025
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Extracellular vesicles in fetal-maternal immune tolerance
1University of Wisconsin, Wisconsin, USA.
Abstract:
Two key problems of allo-tolerance during fetal-maternal co-existence are: 1) it's focus must be local, allowing the mother's continued peripheral immune competence to resist pathogens ubiquitously, and 2) it must propagate itself, i.e. continuously recruit new re-enforcements of the local tolerant state. Both are solved by the exosomal pathway of Tregs & Bregs. While the fetal-maternal accomodations of pregnancy terminate at the time of partrurition, geography, climate and the endemic pathogens of the environment surrounding the mother-baby pair would then define the short and long-term effects of their immunologic interaction.
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