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Association of gut microbiota with acute kidney injury: a two-sample Mendelian randomisation and case-control study

Y Liu1, J Zhang1, Y Zhou1

  • 1Department of Critical Care Medicine, First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, Heilongjiang Province 150001, China P.R.

Beneficial Microbes
|August 30, 2024
PubMed

Insights

The gut bacterium Flavonifractor id.2059 may protect against acute kidney injury (AKI). Higher abundance of this genus was linked to reduced AKI risk and better survival rates in patients.

Area of Science:

  • Microbiology
  • Nephrology
  • Genetics

Background:

  • Epidemiologic studies suggest a link between gut microbiota and acute kidney injury (AKI).
  • The precise causal relationship between specific gut bacteria and AKI development remains unclear.
  • Previous research highlights the need to exclude confounding factors and reverse causality in gut microbiota-AKI associations.

Purpose of the Study:

  • To investigate the causal role of gut microbiota in the development of acute kidney injury (AKI).
  • To identify specific gut microbial taxa associated with AKI risk using robust genetic methods.
  • To explore the potential protective effects of gut bacteria against AKI.

Main Methods:

  • Mendelian randomization (MR) study utilizing large-scale genome-wide association study (GWAS) data for gut microbiota and AKI.
  • Exposure data from MiBioGen Alliance (n=13,266) for intestinal microbiota and outcome data from FinnGen Alliance for AKI (2,383 cases, 212,841 controls).
  • Confirmatory case-control study (42 patients) including phylogenetic and correlation analyses.

Main Results:

  • Evidence of a protective causal association between the genus Flavonifractor id.2059 and AKI (OR=0.48, P=0.0003).
  • Higher relative abundance of Flavonifractor id.2059 in septic non-AKI patients compared to septic AKI patients (P=0.0169).
  • Increased Flavonifractor id.2059 abundance in surviving AKI patients versus non-survivors (P=0.0281), and a negative correlation with creatinine levels (Spearman r=-0.379, P=0.013).

Conclusions:

  • The genus Flavonifractor id.2059 is associated with a reduced risk of acute kidney injury.
  • Findings suggest Flavonifractor id.2059 may have protective implications for AKI prevention and treatment.
  • Further research into specific microbial interventions targeting Flavonifractor id.2059 could offer novel therapeutic strategies for AKI.

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