Related Experiment Video
Updated: Jun 14, 2025
07:36
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.3K
Risk factors for neonatal hypoglycemia: a meta-analysis
Dandan Wang1, Xuchen Zhou2, Juan Ning2
1Department of Neonatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, P. R. China.
BMC Endocrine Disorders
|August 30, 2024
Summary
Caesarean section, small for gestational age, and maternal conditions like gestational diabetes and hypertension are key risk factors for neonatal hypoglycemia. Respiratory distress syndrome also significantly increases risk in newborns.
Area of Science:
- Neonatal Medicine
- Perinatal Health
- Public Health
Background:
- Neonatal hypoglycemia is a common yet serious condition affecting newborns.
- Identifying risk factors is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To conduct a meta-analysis investigating significant risk factors associated with neonatal hypoglycemia.
- To synthesize evidence from multiple case-control studies to provide a comprehensive overview.
Main Methods:
- A systematic literature search was performed across PubMed, Embase, Cochrane Library, and Web of Science databases.
- Case-control studies published up to October 1, 2023, were included.
- Data analysis was conducted using Stata 15.0.
Main Results:
- The meta-analysis included 12 studies with 991 neonates in the hypoglycemic group and 4388 in the non-hypoglycemic group.
- Significant risk factors identified include caesarean section (OR=1.90), small gestational age (OR=2.88), gestational diabetes (OR=1.65), gestational hypertension (OR=2.79), and respiratory distress syndrome (OR=5.33).
Conclusions:
- Caesarean section, small gestational age, gestational diabetes, gestational hypertension, and respiratory distress syndrome are confirmed risk factors for neonatal hypoglycemia.
- These findings highlight the importance of monitoring and managing these factors in at-risk pregnancies and newborns.
Related Concept Videos
01:20Pathophysiology of Diabetes
908
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
908
01:15Hypoglycemia and Glucagon
217
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
217
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
01:22Diabetes Mellitus: Overview and Type I Subtype
2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
01:20Inborn Errors of Metabolism
146
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
146