Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cultivating health resilience in Singapore: a qualitative study from the perspectives of community-dwelling adults and care providers.

BMJ public health·2026
Same author

Co-designing a Palliative Care Referral Tool for Patients with Fibrosing Interstitial Lung Disease.

Annals of the American Thoracic Society·2026
Same author

Integrating Spiritual Values and Clinical Priorities into End-of-Life care: Compassionate Extubation.

Journal of pain and symptom management·2026
Same author

Place of death outcomes of home ventilation patients in Singapore: a retrospective cohort study using a linked database.

Annals of palliative medicine·2026
Same author

Effect of comprehensive geriatric assessment and supportive care on quality of life in older patients with cancer receiving curative treatment: The GOSPEL randomised controlled trial.

Journal of geriatric oncology·2026
Same author

Evaluating the impact of a home palliative programme for terminally ill non-cancer patients with end-stage organ failure and severe frailty in Singapore.

BMC palliative care·2026

Related Experiment Video

Updated: Jul 11, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

10.9K

The PROgnostic ModEl for chronic lung disease (PRO-MEL): development and temporal validation.

Sheryl Hui-Xian Ng1, Zi Yan Chiam2, Gin Tsen Chai3,4

  • 1Health Services and Outcomes Research, National Healthcare Group, Annex @ National Skin Centre, 1 Mandalay Road, Singapore, 308205, Singapore. Sheryl_hx_ng@nhg.com.sg.

BMC Pulmonary Medicine
|August 30, 2024
PubMed
Summary

A new prognostic model predicts one-year mortality in patients with chronic lung diseases (CLDs). This tool aids early palliative care referrals for patients at high risk of deterioration.

Keywords:
BronchiectasisEnd-of-lifeInterstitial lung diseaseLungPrognosticRespiratory

More Related Videos

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

3.2K
An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.0K

Related Experiment Videos

Last Updated: Jul 11, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

10.9K
Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis
07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

3.2K
An R-Based Landscape Validation of a Competing Risk Model
05:37

An R-Based Landscape Validation of a Competing Risk Model

Published on: September 16, 2022

2.0K

Area of Science:

  • Pulmonary Medicine
  • Geriatrics
  • Palliative Care

Background:

  • Chronic lung diseases (CLDs) present a significant symptom burden in advanced stages.
  • Palliative care referrals for CLD patients are often delayed.
  • Existing prognostic tools may lack generalizability across diverse CLD types.

Purpose of the Study:

  • To develop and validate a generalized prognostic model for predicting one-year mortality in patients with any CLD.
  • To improve early identification of CLD patients requiring palliative care assessment.

Main Methods:

  • Retrospective cohort study utilizing electronic medical records from July 2016 to October 2017.
  • Development and validation of a logistic regression model to predict all-cause mortality within one year of diagnosis.
  • Multiple imputation for missing data and assessment of model discriminative ability, calibration, and clinical usefulness.

Main Results:

  • The final model, selected via forward stepwise variable selection, included ten prognostic factors.
  • The model demonstrated good discriminative ability with an AUC of 0.77 (0.72-0.82) in the development cohort and 0.75 (0.70-0.81) in the validation cohort.
  • The model accurately identified 30% of decedents and 90% of survivors when classifying patients with a predicted risk of death exceeding 0.30 as high risk.

Conclusions:

  • A validated prognostic model for one-year mortality in CLD patients was developed using administrative data.
  • This model supports clinicians in identifying at-risk patients across various CLD etiologies.
  • Early identification facilitates palliative care assessment and timely referral, addressing unmet patient needs.