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Updated: Jun 14, 2025
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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
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Inorganic nanoparticles incorporated with transdermal drug delivery systems.
Sukaina Nimrawi1, Peter Gannett1, Young M Kwon1
1Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA.
Expert Opinion on Drug Delivery
|August 31, 2024
Summary
This review highlights the benefits of using inorganic nanoparticles (NPs) to enhance transdermal drug delivery (TDD). Further research is encouraged to explore this promising combination for improved drug permeability.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biomedical Engineering
Background:
- Transdermal drug delivery (TDD) offers a noninvasive alternative to oral administration, bypassing absorption and metabolism issues.
- The skin's barrier properties significantly limit the efficacy of TDD for many drugs.
- Nanoparticles (NPs) are being investigated as passive enhancers to improve transdermal permeability.
Purpose of the Study:
- To review the benefits of incorporating inorganic nanoparticles (NPs) into transdermal drug delivery (TDD) systems.
- To address the current scarcity of research on combining inorganic NPs with TDD.
- To summarize the advantages of inorganic NPs and TDD in pharmaceutical applications.
Main Methods:
- Literature review of existing research on inorganic nanoparticles and transdermal drug delivery.
- Analysis of the potential synergistic effects of combining inorganic NPs with TDD.
- Identification of research gaps and future directions in this field.
Main Results:
- Inorganic NPs show potential for enhancing drug permeability through the skin in TDD.
- Combining inorganic NPs with TDD offers a novel approach to overcome skin barrier limitations.
- Limited studies currently exist that explore this combination, indicating a significant research gap.
Conclusions:
- There is a substantial need for increased research into the integration of inorganic NPs with TDD systems.
- Exploring the advantages of this combination can advance the field of drug delivery.
- Scientists are encouraged to investigate this promising area to unlock new therapeutic possibilities.
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