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Updated: Jun 14, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

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An unexpected degradation pathway of N-hydroxy-5-methylfuran-2-sulfonamide (BMS-986231), a pH sensitive prodrug of

Yande Huang1, Amy Sarjeant2, Roger Sommer2

  • 1Chemical Process Development, Global Product Development and Supply, Bristol Myers Squibb Company, New Brunswick, New Jersey, USA.

Journal of Pharmaceutical Sciences
|August 31, 2024
PubMed

Keywords:
Degradation productsHNOLiquid-chromatography-high resolution mass spectrometry (LC-HRMS)Single crystal X-ray crystallographyStability

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