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Physical Properties of Amines

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Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.

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Updated: Jun 14, 2025

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples

Published on: September 28, 2022

Alkaloids from Anacyclus pyrethrum.

Hui Chen¹, Haji Akber Aisa²

¹State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Chinese Academy of Sciences, South Beijing Road 40-1, Urumqi, China; University of Chinese Academy of Sciences, No.19(A) Yuquan Road, Shijingshan District, Beijing, 10004, China.

|August 31, 2024

Summary

This summary is machine-generated.

Twelve new alkaloids were isolated from Anacyclus pyrethrum roots. Some compounds, anacyquinolines G and H, demonstrated potential anti-inflammatory activity by inhibiting nitric oxide production.

Keywords:

Alkaloids Anacyclus pyrethrum Anti-inflammatory activity Asteraceae

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Last Updated: Jun 14, 2025

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Published on: October 2, 2016

Area of Science:

Natural Product Chemistry
Pharmacognosy
Medicinal Chemistry

Background:

Anacyclus pyrethrum (L.) DC. is a medicinal plant with a history of traditional use.
The chemical constituents of Anacyclus pyrethrum roots are not fully elucidated.
Alkaloids are a diverse class of natural products with significant pharmacological activities.

Purpose of the Study:

To isolate and characterize novel alkaloids from Anacyclus pyrethrum roots.
To investigate the potential anti-inflammatory bioactivity of the isolated compounds.

Main Methods:

Isolation of alkaloids using chromatographic techniques.
Structure elucidation through comprehensive spectroscopic analyses (NMR, HRESIMS, UV, IR).
Confirmation of structures using quantum chemical calculations (ECD, DP4+) and single-crystal X-ray diffraction.

Main Results:

Twelve previously undescribed alkaloids were identified: eight pyrrolo[3,2-g]isoquinoline alkaloids (1-6) and four pyrrolo[2,3-g]quinoline alkaloids (7-9).
The structures of all isolated alkaloids were rigorously determined.
Anacyquinolines G (7a/7b) and H (8) exhibited inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells, with IC50 values of 41.4, 44.1, and 31.4 μM, respectively.

Conclusions:

The study successfully identified twelve new alkaloids from Anacyclus pyrethrum.
Anacyquinolines G and H possess potential anti-inflammatory properties, warranting further investigation.