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Matrix metalloproteinases as the critical regulators of cisplatin response and tumor cell invasion

Iman Akhlaghipour1, Meysam Moghbeli2

  • 1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

European Journal of Pharmacology
|August 31, 2024
PubMed

Insights

Matrix metalloproteinases (MMPs) contribute to cisplatin resistance in cancer by affecting cell invasion and survival pathways. Understanding MMP roles may identify new prognostic markers and therapeutic targets for cisplatin-resistant cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Cisplatin (CDDP) is a key chemotherapy drug for many cancers.
  • Cisplatin resistance presents a significant clinical challenge, impacting treatment efficacy.
  • Identifying mechanisms of resistance is crucial for improving patient outcomes and reducing side effects.

Purpose of the Study:

  • To review the role of Matrix Metalloproteinases (MMPs) in cisplatin response and tumor cell invasion.
  • To explore MMPs as potential prognostic markers and therapeutic targets in cisplatin-resistant cancers.

Main Methods:

  • Comprehensive literature search of PubMed, Scopus, Google Scholar, and Web of Science.
  • Keywords used: "MMP", "cisplatin", and "cancer".
  • Data retrieval limited to publications up to April 20, 2024.

Main Results:

  • MMPs are implicated in regulating tumor cell invasion and extracellular matrix degradation.
  • MMPs can enhance cisplatin resistance through various molecular pathways, including PI3K/AKT, MAPK, and NF-κB signaling.
  • MMPs also influence cisplatin resistance independently via regulation of structural proteins, autophagy, and epithelial-to-mesenchymal transition (EMT).

Conclusions:

  • Matrix metalloproteinases play a significant role in the development of cisplatin resistance in cancer.
  • MMPs represent promising prognostic markers for predicting patient response to cisplatin therapy.
  • Targeting MMPs could offer novel therapeutic strategies for overcoming cisplatin resistance in various malignancies.
Keywords:
ChemotherapyCisplatinMatrix metalloproteinasePrognosis

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