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Updated: Jun 14, 2025

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

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Clinical and pathological characterization of tebentafusp-associated skin toxicity: A cohort study with 33 patients

Dirk Tomsitz1, Katrin Kerl2, Lars Einar French3

  • 1Department of Dermatology and Allergy, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.

Journal of the American Academy of Dermatology
|August 31, 2024
PubMed
Abstract

Insights

Tebentafusp treatment for metastatic uveal melanoma frequently causes skin reactions like rashes and depigmentation. These cutaneous side effects may be linked to improved patient survival.

Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Tebentafusp is a new treatment for metastatic uveal melanoma.
  • Cutaneous side effects are common with tebentafusp therapy.

Purpose of the Study:

  • To characterize the diverse skin reactions caused by tebentafusp.
  • To investigate the relationship between skin reactions and patient survival.

Main Methods:

  • Prospective cohort study of 33 patients treated with tebentafusp.
  • Clinical assessment and histological analysis of skin biopsies.
  • Evaluation of survival data in relation to skin toxicity.

Main Results:

  • 78.8% of patients experienced skin toxicity, with symmetrical erythematous patches being most common.
  • Histopathology revealed lymphocytic interface dermatitis with CD8+ T-cell infiltration.
  • Patients with skin reactions had significantly longer median overall survival (34 vs. 4 months).

Conclusions:

  • Tebentafusp commonly induces cutaneous reactions, likely involving melanocytes and lymphocytes.
  • Skin reactions may indicate a positive prognostic marker for survival.
  • This monocentric study has limitations due to a small patient cohort.
Keywords:
drug-associated rashexanthemagp100rashtebentafuspuveal melanoma

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