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Updated: Jun 14, 2025

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
Published on: April 18, 2015
Dupuytren's Contracture: Approach to Treatment and Counseling Patients in 2024
Anthony M Kordahi1, Jignesh V Unadkat1
1Division of Plastic Surgery, University of Chicago, The University of Chicago Medicine & Biological Sciences, 5841 South Maryland Avenue, Room J641, Chicago, IL 60637, USA.
Abstract:
Dupuytren disease is a progressive disease process that causes debilitating flexion contractures of the metacarpophalangeal and proximal interphalangeal joints. There are multiple interventions to choose from, ranging from minimally invasive techniques with little downtime to open surgical excision with a lengthy postoperative rehabilitation. Our understanding of the disease process continues to evolve. Depending on the extent of flexion contracture, needle aponeurotomy and collagenase injection have satisfactory results with moderate long-term efficacy. Surgical palmar fasciectomy continues to be the mainstay treatment of extensive contractures, with durable results.
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