Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

314
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
314
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
The Synapse02:47

The Synapse

124.6K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
124.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transformations of the spatial activity manifold convey aversive information in CA3.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The multiple scales of astrocytic functional units.

Nature neuroscience·2026
Same author

Simulation-based inference at the theoretical limit for fast, robust microstructural MRI with minimal diffusion data.

Communications medicine·2026
Same author

Simulation-Based Inference at the Theoretical Limit: Fast, Accurate Microstructural MRI with Minimal diffusion MRI Data.

bioRxiv : the preprint server for biology·2025
Same author

SpyDen: simplifying molecular and structural analysis across spines and dendrites.

Bioinformatics (Oxford, England)·2025
Same author

DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning.

Nature neuroscience·2025
Same journal

Demonstration of a quantum C-NOT gate in a time-multiplexed fully reconfigurable photonic processor.

Nature communications·2026
Same journal

Nonlinear quantum light source with van der Waals ferroelectric NbOX<sub>2</sub> (X = Br, I).

Nature communications·2026
Same journal

Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis.

Nature communications·2026
Same journal

The long tail of nitrate pollution in groundwater challenges governance of global water quality.

Nature communications·2026
Same journal

Select microbial metabolites promote tau aggregation in a murine tauopathy model.

Nature communications·2026
Same journal

Warming climate has lengthened global intense tropical cyclone seasons.

Nature communications·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2025

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

6.8K

Competitive processes shape multi-synapse plasticity along dendritic segments.

Thomas E Chater1,2, Maximilian F Eggl3,4, Yukiko Goda5,6

  • 1Laboratory for Synaptic Plasticity and Connectivity, RIKEN Center for Brain Science, Wako-shi, Saitama, Japan.

Nature Communications
|August 31, 2024
PubMed
Summary
This summary is machine-generated.

Neurons compete for molecular resources, influencing synaptic plasticity. The distance between stimulated synapses affects how their strength changes, impacting neural communication.

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.5K
Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

338

Related Experiment Videos

Last Updated: Jun 14, 2025

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

6.8K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.5K
Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

338

Area of Science:

  • Neuroscience
  • Cell Biology
  • Computational Biology

Background:

  • Neurons receive numerous inputs on their dendrites, with individual synapses exhibiting activity-dependent plasticity.
  • Synaptic strength changes, termed structural plasticity (sLTP/sLTD), correlate with alterations in dendritic spine head volume.
  • The mechanisms governing how neurons manage plasticity across multiple neighboring synapses remain largely unknown.

Purpose of the Study:

  • To investigate the fundamental processes driving multi-synapse plasticity in neurons.
  • To understand how neurons allocate resources for synaptic strength modifications across space and time.
  • To explore the impact of stimulated synapse number and distribution on synaptic plasticity.

Main Methods:

  • Utilized glutamate uncaging to induce synaptic potentiation (sLTP) at varying numbers of synapses on the same dendritic branch.
  • Developed a computational model featuring a dual role of calcium (Ca2+) in spine growth and shrinkage.
  • Combined experimental data with computational modeling to analyze multi-spine plasticity dynamics.

Main Results:

  • Demonstrated that competition among dendritic spines for essential molecular resources is a primary factor in multi-spine plasticity.
  • Showed that the spatial proximity of simultaneously stimulated spines significantly influences their resulting structural dynamics.
  • Identified a Ca2+-dependent mechanism driving both spine growth (potentiation) and shrinkage (depression).

Conclusions:

  • Competition for molecular resources is a critical determinant of how neurons implement plasticity across multiple synapses.
  • Spatial arrangement of stimulated synapses plays a key role in regulating the magnitude and direction of synaptic plasticity.
  • These findings provide insights into the resource allocation strategies neurons employ to maintain synaptic homeostasis and function.