Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

580
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
580
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

359
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
359
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Is There A Relationship Between Testosterone And Androgen Receptor With Prostatectomy Outcomes?

Is there a relationship between testosterone and androgen receptor with prostatectomy outcomes?

Bárbara Vieira Lima Aguiar Melão1, Sabrina Thalita Dos Reis Faria2, Kátia Ramos Moreira Leite2

  • 1Division of Urology, University of São Paulo Medical School, São Paulo, Brazil.

The Canadian Journal of Urology
|September 1, 2024

Related Experiment Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.0K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

45.5K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

7.6K

View abstract on PubMed

Summary
This summary is machine-generated.

Low testosterone levels in men undergoing prostate cancer surgery correlate with poorer erectile function recovery and higher rates of biochemical recurrence. Higher androgen receptor expression was also noted in men with lower testosterone.

Area of Science:

  • Urology
  • Oncology
  • Endocrinology

Background:

  • Prostate cancer outcomes are difficult to predict, even with existing biochemical recurrence (BCR) predictors.
  • The role of testosterone in localized prostate cancer remains uncertain, unlike its known role in advanced stages.

Purpose of the Study:

  • To investigate the relationship between preoperative testosterone levels and androgen receptor (AR) expression with oncological and functional outcomes in patients after radical retropubic prostatectomy (RRP).

Main Methods:

  • A retrospective analysis of 212 patients who underwent RRP and had at least two preoperative total testosterone measurements.
  • Comparison of oncological and functional outcomes based on testosterone levels.
  • Assessment of AR and AR-V7 expression in tissue samples from a biorepository.
Keywords:
androgen receptorfunctional outcomesoncological outcomesprostate cancer

Related Experiment Videos

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.0K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

45.5K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

7.6K

Main Results:

  • Thirty-two patients (15.1%) had low testosterone levels.
  • Low testosterone was associated with lower erectile function recovery rates at 24 months (53.1% vs. 71.7%, p=0.037).
  • Patients with low testosterone showed higher rates of BCR (21.9% vs. 9.4%, p=0.041) and higher ISUP grade.

Conclusions:

  • Lower preoperative testosterone levels are linked to diminished erectile function recovery and increased BCR rates post-RRP.
  • Higher AR expression was observed in patients with low testosterone (<300 ng/dL), but this did not correlate with different BCR rates.
radical prostatectomy
testosterone