Herpesviruses and human papillomaviruses in saliva and biopsies of patients with orofacial tumors
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View abstract on PubMed
Summary
This summary is machine-generated.This study found a high prevalence of Human Papillomavirus (HPV) and Herpesviruses in saliva and tumor samples from patients with orofacial tumors. These viral infections were associated with longer hospital stays, suggesting a need for further research.
Area Of Science
- Oncology
- Virology
- Oral Medicine
Background
- Orofacial tumors represent a significant health concern, with viral etiologies being increasingly investigated.
- Human Papillomavirus (HPV) and Herpesviruses are known oncogenic agents with potential roles in various cancers.
Purpose Of The Study
- To determine the prevalence of HPV and Herpesviruses in saliva and tissue samples of patients diagnosed with orofacial tumors.
- To explore the association between these viral infections and clinical factors in patients with orofacial tumors.
Main Methods
- Nested multiplex PCR was employed to detect HPV and Herpesviruses in saliva and tumor biopsy samples from 100 patients.
- Data on patient demographics, comorbidities, tumor stage, and length of stay were collected and analyzed.
Main Results
- High prevalence rates were observed: 17.6% for Herpesviruses and 57.0% for HPV in tumors; 48.3% for Herpesviruses and 60.0% for HPV in saliva.
- Epstein-Barr virus (EBV) was the most common herpesvirus (21.3%), and HPV genotypes 42, 43, and 52 were most prevalent.
- HPV DNA was significantly more prevalent in the saliva of patients with orofacial tumors (69.7%) compared to controls (18.2%).
- Malignant orofacial tumors showed a 2-fold increased odds of EBV detection compared to benign tumors.
- Patients with viral infections had a longer median length of stay.
Conclusions
- A high prevalence of Herpesviruses and HPV exists in the context of orofacial tumors, detected in both saliva and tissue.
- The findings suggest a potential etiological or contributory role for these viruses in orofacial tumorigenesis.
- Further research is warranted to elucidate the precise mechanisms and clinical implications of these viral associations.
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