Immediate and prolonged effects of dihydroergocryptine after experimental vascular microsurgery

An animal model of limb replantation has been utilized in order to evaluate the effects of dihydroergocryptine (DHEC, 0.1 mg/kg I.V.) on arterial and peripheral tissular blood flows after reperfusion. DHEC is a partial agonist of adrenergic receptors and is therefore liable to exert an action on arteriovenous shunts that remain abnormally opened after ischaemia. DHEC showed important efficacy in this model, increasing, in low doses, blood flow in sutured artery and peripheral tissue.