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Phloridzin functionalized gelatin-based scaffold for bone tissue engineering.

Parinaz Hobbi1, Forough Rasoulian2, Oseweuba Valentine Okoro1

  • 1Université Libre de Bruxelles (ULB), École Polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50-CP 165/61, B-1050 Brussels, Belgium.

International Journal of Biological Macromolecules
|September 1, 2024
PubMed
Summary
This summary is machine-generated.

This study developed a gelatin scaffold using apple polyphenol phloridzin for bone tissue engineering. The functionalized scaffold supports cell growth and promotes bone formation, showing potential for fruit waste utilization in regenerative medicine.

Keywords:
Bone tissue engineeringPhloridzinPolyphenol-functionalized scaffold

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Biotechnology

Background:

  • Polyphenol-functionalized biomaterials offer antioxidant, anti-inflammatory, and osteoinductive benefits crucial for bone tissue engineering (BTE).
  • Gelatin (Gel) is a widely used biomaterial for BTE scaffolds.
  • Phloridzin (Ph), a polyphenol from apple by-products, presents an opportunity for sustainable biomaterial development.

Purpose of the Study:

  • To functionalize a gelatin-based scaffold with phloridzin (Ph) for bone tissue engineering applications.
  • To evaluate the physicochemical, morphological, and preliminary biological properties of the Ph-functionalized scaffold (Gel/Ph).
  • To investigate the effect of hydroxyapatite nanoparticle (HA) incorporation on the osteogenic potential of the Gel/Ph scaffold.

Main Methods:

  • Fabrication of a gelatin scaffold functionalized with phloridzin (Gel/Ph).
  • Characterization of scaffold porosity, pore size, radical scavenging activity, and Young's modulus.
  • Assessment of cell proliferation and cytocompatibility with mesenchymal stem cells (MSCs).
  • Evaluation of osteogenic gene expression (Runx2, ALPL, COL1A1, OSX) and mineralization in HA-incorporated Gel/Ph scaffolds.

Main Results:

  • The Gel/Ph scaffold exhibited high porosity (71.3 ± 0.3%), suitable pore size (206.5 ± 1.7 μm), and significant radical scavenging activity (>70%).
  • The scaffold demonstrated good mechanical properties (Young's modulus: 10.8 MPa), supported MSC proliferation, and showed cytocompatibility.
  • Incorporation of hydroxyapatite nanoparticles (HA) into the Gel/Ph scaffold significantly stimulated osteogenic gene expression and promoted mineralization.

Conclusions:

  • Phloridzin-functionalized gelatin scaffolds possess favorable physicochemical and biological properties for BTE.
  • The developed biomaterial demonstrates potential for promoting osteogenic differentiation and mineralization.
  • Utilizing fruit waste-derived polyphenols offers a sustainable approach for developing advanced bone tissue engineering scaffolds.